Effects of Diammonium Glycyrrhizinate Enteric Capsule Combined with Bifidobacterium Tetralogy on Inflammatory Indexes and Liver Injury in NAFLD Patients

OBJECTIVE To investigate the effects of diammonium glycyrrhizinate enteric capsule combined with bifidobacterium tetralogy on inflammatory indexes and liver injury in patients with nonalcoholic fatty liver (NAFLD). METHODS From April 2015 to June 2017, 102 NAFLD patients were randomly divided into 2 groups:the observation group and the control group (n=51). The observation group was treated with diammonium glycyrrhizinate enteric capsule combined with bifidobacterium tetralogy, while the control group was treated with diammonium glycyrrhizinate enteric capsule. The therapeutic effect, blood lipid level, liver injury index, lipid peroxidation index, inflammatory index, insulin resistance index, pearson correlation analysis and adverse reaction were compared between the 2 groups. RESULTS The total effective rate of observation group (94.1%) was significantly higher than that of control group (80.4%) (P<0.05). After treatment, blood lipid (TG, TC, LDL-C, HDL-C), liver injury index (ALT, AST, GGT), lipid peroxidation index (SOD, T-GSH, MDA) in observation group were significantly different from that in the control group (P<0.05). Compared with control group, inflammatory index (TNF-α, IL-6, NK-κB, LPS), insulin resistance index (FPG, FINS, HOMA-IR) of observation group were significantly better (P<0.05). After pearson correlation analysis, there was a negative correlation between the activity of SOD, T-GSH and liver injury index (P<0.05). MDA, TNF-α, IL-6, NK-κB, LPS, FINS, HOMA-IR were positively correlated with the liver injury index (P<0.05). There was no significant difference in the incidence of adverse reactions between the 2 groups. CONCLUSION Diammonium glycyrrhizinate enteric capsule combined with bifidobacterium quadruple viable can effectively improve the liver injury in NAFLD patients, which may be related to improving lipid peroxidation, inflammatory reaction and insulin resistance.