Determination of Sodium Dodecyl Sulfate in Fenofibrate Formulation by GC

OBJECTIVE To establish a method for the sodium dodecyl sulfate determination of Fenofibrate formulation. METHODS The capillary column was HP-5 (30 m×0.53 mm, 2.65 μm). The carrier gas was nitrogen and the detector was FID with temperature programming and direct sample injection. The content of sodium dodecyl sulfate was determined by external standard method with 1-dodecanol as reference substance. RESULTS There was good linear relationship of 1-dodecanol in the concentration range of 0.165-1.32 mg·mL^-1, r=0.9995. The dosage of sodium dodecyl sulfate was lower than the safe amount, but some companies might have overadded or illegally added sodium dodecyl sulfate in our country. CONCLUSION The method is accurate, reliable and suitable for the determination of sodium dodecyl sulfate in Fenofibrate formulation.