Optimization of Extraction Technology of Gout Cataplasma by Multicriteria Synthesis Assessment

OBJECTIVE To optimize the extraction process for Gout cataplasma. METHODS The effects of ethanol concentration, ethanol dosage, extraction time and extraction times on the extraction results were investigated by orthogonal design method using the content of sinomenine, total alkaloid and the yield of dry extract as the indexes. RESULTS The optimal process was found as follows:extraction was performed for three times, the total extraction time was 1.5 h, 6-fold 65% ethanol was added each time. The content of sinomenine, total alkaloid and dry extract obtained under the conditions were 2.79 mg·g^-1, 1.22% and 13.06%, respectively. CONCLUSION The optimized extraction process is stable and feasible.