One Case Analysis of Treatment by Methotrexate on Psoriasis Patient with Cerebral Infarction

OBJECTIVE To provide ideas for the clinical course of drug interactions and adverse events by analyzing a case for a psoriasis patient with cerebral infarction treated by methotrexate. METHODS Clinical pharmacist participated in the whole process of a psoriasis patient with cerebral infarction who was suffered severe mucositis and myelosuppression by taking methotrexate. Clinical pharmacist recommended to suspend the antiplatelet drug aspirin, closely monitoring blood routine, coagulation function and so on. RESULTS Physician adopted clinical pharmacist's suggestion, ask patients to stop taking aspirin and use interleukin-11 to elevate platelets while closely monitoring blood routine, blood coagulation function and blood pressure control. The patient was getting better after 10 d, the blood picture was getting normal and arranged discharge. CONCLUSION In clinical work, clinical pharmacists shall actively play its due role in collaboration with clinicians, carry out the monitoring of adverse drug events, and ask patients about the history of previous medication. In order to promote rational drug use and improve treatment effect.