Effect of Placenta Polypeptide Injection Combined with Chemotherapy on Patients with Advanced Gastric Cancer

OBJECTIVE To investigate the clinical efficacy and safety of the placenta polypeptide injection combined with chemotherapy in the treatment of advanced gastric cancer and observe its effect on their immune function. METHODS A total of 78 patients with advanced gastric cancer treated in the 452 Hospital of PLA from May 2015 to May 2017 were randomly divided into control group (39 patients) and observation group (39 patients). Control group was treated with FOLFOX6 chemotherapy alone conventional chemotherapy, observation group treated with the placenta polypeptide injection on the basis of control group's treatment. After 3 courses of treatment, the recent clinical efficacy, quality of life, immune function and adverse reactions were observed and compared in the two groups of patients. RESULTS After 3 courses of treatment, the total effective rate (66.67%) in observation group was significantly better than that in control group (53.85%) (P<0.05). The quality of life improvement (Karnofsky score) and improvement of body mass in the observation group were significantly better than those in the control group (P<0.05). The incidence of gastrointestinal reactions, myelosuppression, and leukopenia were significantly lower in the observation group than in the control group (P<0.05). Before treatment, there were no significant differences in immune function indexes of CD₃⁺, CD4⁺, CD4⁺/CD8⁺ and NK cells between the two groups. After 3 courses of treatment, there were no significant changes in immune function indicators in the control group. In addition to CD8⁺, other immune function indicators were significantly increased in observation group (P<0.05). CONCLUSION The placenta polypeptide injection combined with chemotherapy for advanced gastric cancer is not only clinically effective, but also can reduce the adverse reactions caused by chemotherapy, and has a significant improvement in the patient's immune function and quality of life.