Clinical Study of Glutamine Combined with Magnesium Isoglycyrrhizinate on Severe Acute Pancreatitis

OBJECTIVE To explore the clinical efficacy of glutamine combined with magnesium isoglycyrrhizinate in the treatment of severe acute pancreatitis(SAP) and its effects on inflammatory factors and intestinal mucosal barrier function. METHODS A total of 80 patients with SAP from February 2014 to February 2017 were enrolled and randomly divided into control group and combination group, 40 cases in each group. Both groups were given routine treatment. Control group were given glutamine 0.3 g·kg^-1·d^-1 on the basis of enteral nutrition, while combination group were given intravenous infusion of magnesium isoglycyrrhizinate 150 mg added into 5% glucose injection 250 mL on the basis of control group, once daily. Both groups were treated for 14 d. The efficacy and APACHE Ⅱ score, level of IL-6, IL-8, IL-10 and TNF-α, intestinal mucosal barrier function index of diamine oxidase(DAO), D-lactate, endotoxin(ET) were compared before treatment and 3th,7th,14th day of treatment in two groups.RESULTS The total effective rate in combination group was 92.50%, which was significantly higher than that of 75.00% in control group(P<0.05). On the 3th, 7th, 14th day of treatment, the scores of APACHE Ⅱ in combination group was significantly lower than that in control group(P<0.05). The levels of serum TNF-α, IL-6, IL-8 in combination group were significantly lower than those in control group while the level of serum of IL-10 was significantly higher(P<0.05). The levels of serum DAO, D-lactate, ET in combination group were significantly lower than those in control group(P<0.05). CONCLUSION Glutamine combined with magnesium isoglycyrrhizinate in the treatment of SAP can improve clinical efficacy, which can effectively reduce inflammation, improve intestinal mucosal barrier function.