Association Effect of Oleanolic Acid on the Function of OATP1B1

OBJECTIVE To investigate the association effect of oleanolic acid(OA) on organic anion transporting polypeptide1B1(OATP1B1) transport function. METHODS Using human embryonic kidney 293(HEK293) cells stably expressing OATP1B1, to observe the effect of OA on OATP1B1-mediated uptake of fluvastatin(FV). RESULTS OA could competitively inhibit the OATP1B1-mediated uptake of FV, with the ki values of (20.3±2.1)mmol·L^-1. CONCLUSION Inhibitory effect of OA on transporter function of liver drug transporter OATP1B1 can induce hurb-drug interactions.