JNK Signaling Pathway and Islet Beta Cell Apoptosis

c-Jun N-terminal kinase (JNK) signaling pathway is found in recent years and is one of the pathways of closely related to mechanism of cell apoptosis, shock response as well as the occurrence and development of diabetes, which its biological effect is important for the regulation of islet beta cells. According to different stimuli, the JNK is mediated three activation of apoptotic pathways, including death receptor pathway, mitochondrial apoptosis pathway and endoplasmic reticulum stress activation pathway, between various pathways to a factor or stimuli and produce crosstalk relationship. Reactive oxygen species (ROS) as a source of stress can activates JNK signaling pathway, so then excited apoptosis pathway. Therefore, to adjust and control on every node of the JNK signaling pathway, which are likely to reduce the number of islet beta cell apoptosis, protect pancreatic tissue integrity, reduce the risk of diabetes and complications.