Effect of Intensive Lipid-lowering Therapy on Serum mTOR and Tau Protein Levels in Patients with Acute Cerebral Infarction

OBJECTIVE To investigate the effect of intensive lipid-lowering therapy on serum mTOR and Tau levels in patients with acute cerebral infarction. METHODS One hundred and twenty patients aged 40-60 years old, weighing 50-80 kg with acute cerebral infarction were randomly divided into 2 groups (n=60 each group):control group, intensive lipid-lowering therapy group. The control group were treated with conventional treatment and atorvastatin (10 mg·d^-1, qd). the intensive lipid-lowering therapy group were treated with conventional treatment and atorvastatin (40 mg·d^-1, qd). Venous blood samples were obtained for determination mTOR, Tau, NF-κB and IL-6 concentrations by ELISA. NIHSS scale were performed to evaluate the neurdogical deficit in patients. RESULTS Compared with control group, the serum mTOR, Tau, NF-κB, IL-6 and NIHSS score of intensive lipid-lowering therapy group were significantly lower (P<0.05). Compared with before treatment, the serum mTOR, Tau, NF-κB, IL-6 and NIHSS score of intensive lipid-lowering therapy group were significantly lower after treatment (P<0.05). CONCLUSION Intensive lipid-lowering can reduce inflammatory response in patients with acute cerebral infarction, and improve the stability of vulnerable plaque. The possible mechanism may be related to reduce the concentration of serum mTOR and Tau.