Systematic Review on Naoxintong Capsule Combined with Statins in Treatment of Hyperlipidemia

OBJECTIVE To evaluate the efficacy and safety of Naoxintong capsule combined with statins in treating hyperlipidemia. METHODS We searched the Cochrane library, PubMed, Embase, Medline, CNKI, CBM, VIP and Wanfang database for RCTs, and analized by Revman 5.3 software. RESULTS Fourteen RCTs, a total of 1 244 subjects were included. Compared with the statins alone, the total effect of lipid of Naoxintong capsule combined with statins was higher than that in control groupRR=1.20, 95%CI (1.10, 1.31), P<0.000 1, the TC level after treatment of Naoxintong capsule combined with statins was lower than that in control groupWMD=-0.79, 95%CI (-1.06, -0.53), P<0.000 01, the heterogeneity of subgroup of Naoxintong capsule combined with Atorvastatin Calcium was low (P=0.09, I²=48%). The TG level after treatment of combined group was lower than control groupWMD=-0.68, 95%CI (-0.92, -0.45), P<0.000 01, the HDL-C level after treatment of combined group was higher than control groupWMD=0.28, 95%CI (0.18, 0.37), P=0<0.000 01, the LDL-C level after treatment of combined group was lower than that in control groupWMD=-0.53, 95%CI (-0.87, -0.18), P=0.003. The incidence of adverse reactions in each group showed no significant differenceRR=2.25,95%CI (0.71,7.16),P=0.17. CONCLUSION Naoxintong capsule combined with statins may more effectively improve hyperlipidemia, including TC, TG, HDL-C and LDL-C, the efficiency of combined with statins for TC is exactly and there is no significant difference of adverse reactions compared with other drugs, this article recommend it used in the treatment of hyperlipidemia in clinical and to add more high quality researches.