Determination of Three Effective Components and Preservatives in Compound Yuxingcao Mixture

OBJECTIVE To investigate the quatity of compound Yuxingcao mixture in market. METHODS Collected 10 batches of Compound Yuxingcao mixture from different manufacturers, HPLC was applied to determine the content of 3 effective compoents (chlorogenic acid, forsythoside A and baicalin) and the content of preservatives (sodium benzoate and ethylparaben). RESULTS The content of chlorogenic acid of the 10 batchs of Compound Yuxingcao mixture was 29.74-84.13 μg·mL^-1, the content of forsythoside A was 22.69-113.44 μg·mL^-1, the content of baicalin was 0.587-1.662 mg·mL^-1; The contents of sodium benzoate and ethylparaben were all met the standard. CONCLUSION The quality situation of Compound Yuxingcao mixture is optimistic, but there are differences in quality of different batches. The quality control method of Compound Yuxingcao mixture is simple and can not effectively control the quality, shall revise and improve the standard.