Preparation of Myricanol and Myricanol 5-fluorobenzyloxy Ether and its Effect on the Activity of HepG₂ Cells

OBJECTIVE To observe the activity of myricanol and myricanol 5-fluorobenzyloxy ether (5FEM) on liver cancer of cell HepG₂in vitro. METHODS Myricanol (25, 12.5 and 6.25 μg·mL^-1) and 5FEM (25, 12.5 and 6.25 μg·mL^-1) were prepared to act on HepG₂ cells, real time cellular analysis was used to record 96 h cell index (CI) to observe the effect of Myricanol and 5FEM on the proliferation and migration of HepG₂ cells. RESULTS Myricanol and 5FEM could inhibit the proliferation and migration of HepG₂ cells, showing a dose-effect curve. The effect of 5FEM was better than myricanol at the same dose. CONCLUSION Myricanol and 5FEM can effectively inhibit the proliferation and migration of HepG₂ cells.