Meta-analysis of the Efficacy and safety of Lacidophilin Vaginal Capsules Combined with Antifungal Suppositories in Sequential Treatment of Vulvovaginal Candidiasis During Pregnancy

OBJECTIVE To evaluate the efficacy and safety of Lacidophilin Vaginal capsules combined with antifungal suppositories in sequential treatment of vulvovaginal candidiasis during pregnancy by meta-analysis. METHODS PubMed, EMbase, Cochrane libraries, CNKI, Wanfang and VIP were searched to collect pertinent references(from their inception to December, 2016). Data were extracted and evaluated by two reviewers independently with a designed extraction form. The RevMan 5.2 software was used to carry out meta analysis. RESULTS A total of 15 studies involving 2 522 patients were included. The results of meta-analysis indicated that the cure rate of Lacidophilin Vaginal capsules combined with antifungal suppositories was significantly higher than that of antifungal suppositories(P<0.000 01). The recurrence rate of Lacidophilin Vaginal capsules combined with antifungal suppositories significantly decreased than that of antifungal suppositories (P<0.000 01). There was no significant differences between the adverse drug reaction(ADR) occurrence of Lacidophilin Vaginal capsules combined with antifungal suppositories and antifungal suppositories (P=0.68). CONCLUSION Lacidophilin Vaginal capsules combined with antifungal suppositories in the treatment of vulvovaginal candidiasis during pregnancy is more effective than antifungal suppositories, with lower recurrence rate.