Preparation of Bosentan Tablet

OBJECTIVE to optimize the prescription of bosentan tablet, and in order to solve the common problem of dissolution and chemical stability. METHODS Tablets characters, dissolution, related substance and stability of crystal was used as the research index to compare the methods of preparating Bosentan tablet including original drugs, so as to get optimized method. RESULTS The tablets made by the best method (as tabletting after wet granulation after optimization) were one sided smooth and had beautiful appearance, high solubility, stable crystal and related substance according to requirement, especially the solubility activity and quality being compliant with original drug. CONCLUSION The new method can solve the problem of dissolution and chemical stability, can get tablets excellent quality of original drug, being simple and feasible to realize industrial production.