Safety of Continuation of Pregnancy after First-trimester exposure to Mifepristone and Prostaglandin

OBJECTIVE To assess the safety of continuation of pregnancy after first-trimester exposure to mifepristone. METHODS We searched China National Knowledge Infrastructure(CNKI), Wanfang Database, Chinese Scientific Journals Full-text Database(VIP), Web of Science, Pubmed. Randomized controlled trials(RCT) of the safety of continuation of pregnancy after first-trimester exposure to mifepristone were collected. Data analyses were performed with The RevMan 5.3 software. A total of 4 RCTs were included. RESULTS The results showed that, compared with control group, the pregnant women taking mifepristone for emergency contraception but failing to abort the fetus have higher rate of the adverse reaction(OR=6.09, 6.72). The rate of the neonatal asphyxia is significantly higher than the control group (OR=7.65, 95%CI 3.13-18.69). The rate of neonatal malformation of continuation of pregnancy after first-trimester exposure to mifepristone there was no significant differenc compared with the group which the mifepristone was associated with prostaglandin analogue (OR=0.45, 95%CI 0.12-1.73). CONCLUSION The pregnant women taking mifepristone during first-trimester have higher adverse reaction than the normal pregnant women. However, more randomized controlled trials with large sample size and quality are required to provide further evidences.