Study on the Synthesis and Properties of Nifedipine Self Microemulsion System

OBJECTIVE To improve the bioavailability of nifedipine by the preparation of micro-emulsified. METHODS Using transmission electron microscope and Zeta potential analyzer for the average particle of nifedipine self microemulsion size and particle size distribution, morphological characteristics, surface potential, stability, release in vitro and absorption in vivo characteristics of initial quality evaluation. RESULTS The average diameter size of nifedipine self-emulsion was 25~26 nm. The average particle the distribution was more concentrated; particle shape, uniform size; surface potential was -(25.1+1.1)mV; the in vitro release rate was >90%. CONCLUSION The drug has made nifedipine self-emulsion which has good absorption in vivo.