Study on Acute Alcohol Liver Injury Induced by Jiejiu Oral Liquid in Mice

OBJECTIVE to investigate the protective effect of Jiejiu Oral Liquid on acute alcoholic liver injury in mice. METHODS The mice were randomly divided into 6 groups, 10 rats in each group:normal group, bifendate group (11.7 mg·kg^-1), model group and low, medium, high dose(6.25, 12.5, 25 g·kg^-1) group. Mice were administered 1 times a day for 14 d. except for the normal control mice were given 56 degrees of Beijing Red Star Erguotou according to 12 ml·kg^-1 single dose by intragastric administration. twelve hours later, the mice were killed to take blood samples and liver tissue specimens. then compared the liver index, histological examination of liver tissue, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity level. RESULTS the serum ALT, AST, the fatty vacuoles in liver and the inflammatory symptoms were significantly reduced in alcohol induced acute liver injury mice, liver index was significantly improved in acute liver injury. CONCLUSION Jiejiu Oral Liquid has a protective effect on acute alcoholic liver injury in mice.