Determination of Tetracaine Hydrochloride Which Illegal Added in Male External Products by UHPLC-Q-TOF-MS

OBJECTIVE To establish a high performance liquid chromatography-quadrupole time of flight mass spectrometry (UHPLC-Q-TOF-MS) method for detection of tetracaine hydrochloride which illegal added in male external products. METHODS Samples were separated by C₁₈ chromatographic column, mobile phase was 0.05% formic acid solution-acetonitrile with gradient elution, TOF and Target MS/MS scanning mode was adopted. RESULTS Confirmed by standard, tetracaine hydrochloride were detected in samples. CONCLUSION The method can be used for rapid identification tetracaine hydrochloride illegally added in male external products.