Dynamic Analysis of Distribution and Antimicrobial Resistance of Cesarean Section Postoperative Infection of Elderly Maternal

OBJECTIVE To investigate the profile of distribution and antimicrobial resistance of cesarean section postoperative infection of elderly maternal. METHODS Three years as a time period, elderly maternal with cesarean section postoperative infection were enrolled in the study from January 2007 to December 2015 in our hospital, then the pus or secretions was sampled from the incision sites, the culture, isolation, and identification of the pathogenic bacteria were performed. RESULTS The 77 strains, 74 strains and 75 strains were isolated from 2007 to 2009, from 2010 to 2012 and from 2013 to 2015, respectively, most of them were Staphylococcus aureus, coagulase-negative Staphylococci, Escherichia coli and Pseudomonas aeruginosa. Dynamic analysis of bacteria distribution showed that infections caused by Gram-positive bacteria was gradually decreased, but Gram-negative bacterial infection was gradually increased. Among them, the proportion of Escherichia coli infection increased most significantly. Drug sensitivity results suggested that, drug resistance of Gram-positive bacteria on Vancomycin and Rifampicin were lower, and Gram-negative bacterial of Escherichia coli, Pseudomonas aeruginosa on Imipenem, Meropenem, Piperacillin tazobactam, Cefoperazone sulbactam and Amikacin were lower. Dynamic analysis of antimicrobial resistance showed that drug resistance of Staphylococcus aureus on ceftriaxone, levofloxacin, and Escherichia coli on levofloxacin, and Pseudomonas aeruginosa on Piperacillin tazobactam and Ceftazidime increased significantly. CONCLUSION Staphylococcus aureus, coagulase negative Staphylococci, Escherichia coli and Pseudomonas aeruginosa are the common pathogenic bacteria in cesarean section postoperative infection of elderly maternal, Gram-positive bacteria is gradually decreased, and Gram-negative bacterial infection is gradually increased. Drug sensitivity results show that the multi-drug resistance of pathogenic bacteria to common antibiotics is serious, and the antibiotics should be reasonably used.