Effect of Different Crystal Types of Telmisartan on the Dissolution Behavior of Preparation

OBJECTIVE To study the crystal types of telmisartan in different tablets with Raman spectrometer, and the effect of different crystal types on the dissolution behavior of tablets. METHODS Raman spectrum was used in the analysis of crystal types. The dissolution apparatus Ⅱ was used with speed of 50 r·min^-1. RESULTS The result showed there was three crystals of telmisartan in five batches of samples, and the dissolution behaviors of different crystal types had some differences. CONCLUSION API crystal type has bigger effect on the drug dissolution, enterprise should pay attention to the effect of crystal type on the drug during the producing.