Advances in Oral Colon Targeted Drug Delivery System Based on Inflammation

Oral colon targeted drug delivery is an active area of research for local diseases affecting the colon, as it improves the efficacy of therapeutics and reduces systemic toxicity. Advances in oral drug delivery design have significantly improved the bioavailability of drugs to the colon; however in order to have therapeutic efficacy for a drug during disease, considerations must be made for the altered physiology of the gastrointestinal (GI) tract that is associated with GI inflammation. Nanotechnology has been used in oral dosage formulation design as strategies to further enhance uptake into diseased tissue within the colon. This review will summarize the major design methods of nano-delivery systems and the research progress.