Influence of Phellinus Igniarius Polysaccharides on Growth and Peripheral Blood Cells of Rats Treated by Cyclophosphamide

OBJECTIVE To study the effects of Phellinus igniarius polysaccharides on growth and peripheral blood biochemical indexes of normal rats or immune-injury rats induced by cyclophosphamide. METHODS Immunosuppressive rats model were induced by intraperitoneal injection of cyclophosphamide. The rats were randomly divided into four groups, each group of rats after intraperitoneal injection of appropriate drugs 7 d, continuous oral administration of appropriate drugs 28 d, after the rats were put to death by femoral artery blood sampling, The spleen and thymus of rats were stripped, spleen and thymus wet weight, and viscera index was calculated, peripheral blood leukocytes(WBC) count, hemoglobin(Hb) content, protein content and AKP, LDH activity were dected by routine blood test. RESULTS Compared with control group, the weight of rats, the wet weight index of thymus and spleen, the WBC counts, the content of Hb, the contents of total protein and globulin were significantly increased by Phellinus igniarius polysaccharides. And coulud deter the induced inhibition of cyclophosphamide. CONCLUSION Phellinus igniarius polysaccharides can improve and regulate the nutritional status of rats and hematopoietic function, thereby enhancing the body's immune function.