Effect of Oleanolic Acid on the Pharmacokinetics of Fluvastatin in Rats

OBJECTIVE To explore the effect of oleanolic acid(OA) on the metabolism of fluvastatin in rats. METHODS Sixteen health rats were randomly divided into two groups: the single group(fluvastatin 5.0 mg·kg^-1) and the combined group(fluvastatin 5.0 mg·kg^-1+OA 60 mg·kg^-1). The single group were administrated with blank solution while the combined group were administrated with the same volume of OA, the administration period of 5 d. At the sixth day, both groups were administrated with fluvastatin, plasma concentrations of fluvastatin were determined by LC-MS. The main pharmacokinetic parameters were calculated and compared. RESULTS The main pharmacokinetic parameters(C_max, AUC_0-t) of the combined group showed increased remarkably compared with the single group. Statistically significant difference was showed between groups(P<0.05). CONCLUSION OA can affect the pharmacokinetic parameters of fluvastatin in rats.