Correlation between Response Variability of Platelet Aggregation Inhibitors and Seattle Angina Questionnaire in Early Stage Undergoing Percutaneous Coronary Intervention Patients

OBJECTIVE To assess the correlation between response variability of aspirin and clopidogrel detecting by thromboelastography(TEG) and Seattle angina questionnaire(SAQ) in early stage undergoing percutaneous coronary intervention (PCI) patients.METHODS Forty-three post-PCI patients were detected maximum amplitude(MA) and inhibition rate(IR) of arachidonic acid(AA) and adenosine diphosphate(ADP) using TEG. According to AA-IR, aspirin response variability defined as: low(<50%), medium(50%-85%) and high(>85%). According to ADP-MA, clopidogrel response variability defined as: low (>47 mm), medium(31-47 mm) and high(<31 mm). The patients were divided into 3 groups by antiplatelet drug response variability: combined high response group, combined medium response group and combined low response group. SAQ assessment was performed before and 4 weeks after PCI in all patients. RESULTS Among 3 groups, the gender, age, stent count, and prevalence of hypertension and diabetes had no significant differences. SAQ scores in 3 groups had no significant differences before PCI, and increased 4 weeks after PCI. But SAQ scores in the combined low response group were lower than other groups relatively. Relevant between post-PCI SAQ scores and antiplatelet drugs response was confirmed by Pearson correlation coefficient. CONCLUSION Response variability of aspirin and clopidogrel is associated with SAQ scores in early stage post-PCI patients. Antiplatelet drug low response may be an important risk factor of angina pectoris in early stage post-PCI patients.