Clinical Study on the Effects of Huatan Zhike Mixture on the levels of Serum SAA, IL-6, IL-1β and Lung Function in Acute Exacerbated Chronic Obstructive Pulmonary Disease Patients

OBJECTIVE To investigate the effect of Huatan Zhike mixture on the levels of serum SAA, IL-6, IL-1β and lung function in acute exacerbated chronic obstructive pulmonary disease(AECOPD) patients. METHODS Sixty patients with AECOPD were randomly assigned to the treatment group and the control group. All the patients were treated with routine western medical therapy and the patients in the treatment group were added with Huatan Zhike mixuture orally, with a course of 14 days. The changes of SAA, IL-6, IL-1β, the pulmonary functions and CCQ scores were evaluated before treatment and after treatment. RESULTS before treatment, there were no significant differences in the value of SAA, IL-6, IL-1β, FEV1/FVC and FEV1% between two group(P>0.05). After treatment, the levels of serum SAA, IL-6, IL-1β and CCQ scores were significantly lower than that before treatment(P<0.05); compared with the control group, the levels of serum SAA, L-6, IL-1β and CCQ scores in treatment group were decreased significantly(P<0.05); there were no significant differences between two group in the levels of FEV1% and FEV1/FVC. CONCLUSION Huatan Zhike mixture can reduce the levels of SAA, IL-6 and IL-1β, and improve the clinical symptoms in AECOPD patients. The mechanisms may be related to certain anti-inflammatory effects on improve clinical efficacy of AECOPD patients..