Comparative Study on Effects of Pharmaceutical Intervention on Clinical Therapy for Pulmonary Tuberculosis Patients Complicated with Diabetes Mellitus

OBJECTIVE To evaluate the effects of pharmaceutical intervention on clinical therapy for pulmonary tuberculosis patients complicated with diabetes mellitus. METHODS Used prospective to control study, a total of 124 patients with pulmonary tuberculosis complicated by diabetes mellitus were randomly divided into the no-intervention group(n=61)and the intervention group(n=63). Clinical pharmacists participated in the programs of pharmaceutical intervention in the intervention group. Then the costs, the treatment efficiency, the incidence rate of adverse drug events, the medication compliance and the satisfaction were compared in 2 group. RESULTS The pharmacist carried out 89 recommendations for patients, and 76 (85.39%) of the recommendations were well accepted by the physicians. Compared with the no-intervention group, total costs for per person and drug costs were respectively significantly lower in the intervention group(P<0.05). The sputum negative conversion rate, lesions absorption rate, cavity closure rate and glucose control rate in intervention group were significantly higher than those of the no-intervention group(P<0.05). After pharmaceutical intervention, the drug adherence outstanding rate and pharmacy service satisfaction were significantly better than those in the no-intervention group, whereas the incidence rate of adverse drug events was quite lower (P<0.01). However, there was no significant difference in the average hospitalization time between the no-intervention group and the intervention group. CONCLUSION The whole course pharmaceutical intervention for the pulmonary tuberculosis patients complicated with diabetes mellitus can not only improve the rational use of drugs, the medication compliance, and the satisfaction, and reduce the hospitalization costs, but also provide a basis for the participation in chronic diseases management of clinical pharmacists.