Study of Method for Dissolution Test of Compound Aminopyrine Phenacetin Tablets

OBJECTIVE To establish the dissolution test method for the compound aminopyrine phenacetin tablets.METHODS The established dissolution was the paddle method. 900 mL 0.1 mol·L^-1 hydrochloride acid was used as the dissolution medium, the rotation speed was 50 r·min^-1. HPLC was used for detection. A Kromasil C₁₈ column (250 mm×4.6 mm, 5 μm) was used. Mobile phase consisted of a mixture of monopotassium phosphate solution-methanol (60:40), and UV detection wavelength was 215 nm.RESULTS Obvious difference of dissolution curves between different companies was observed.CONCLUSION The developed method provided a scientific basis for improving the quality control standards, and establishing a reasonable dissolution test method for compound aminopyrine phenacetin tablets.