Evaluation on Antimicrobial Effectiveness of Preservative in Simotang Mixture

OBJECTIVE To evaluate antimicrobial effectiveness of preservative in simotang mixture.METHODS HPLC was adopted to determinate preservative ethylparaben content of simotang mixture. Using S. aureus, P. aeruginosa, E. coli, A. niger and C. albicans as test strains, the antimicrobial effectiveness test was carried out to evaluate the survival of microorganisms at the different time.RESULTS The concentration of ethylparaben in the sample was 0.04%. Simotang mixture had the strong bacteriostasis and poor fungistasis.CONCLUSION The antimicrobial effectiveness of preservative in simotang mixture meets the requirements of the Ch.P (2010), but does not meet the requirements of the Ch.P (2015). The existing antimicrobial formulations need to be optimized.