Effect of Water Extract of Radix Isatidis on Early Liver Injury in Diabetes Mellitus Rats

OBJECTIVE To analysis the influence of water extract of Radix Isatidis(WERI) on liver in diabetic rats.METHODS Diabetic model of Wistar rats induced by streptozotocin. They were randomly divided into model group, rosiglitazone group (0.3 mg·kg^-1), WERI high, medium and low dose group(100, 50, 25 mg·kg^-1). And set up the normal control group, all the use of gastric administration. After 4 weeks, fasting blood glucose (FBG), fasting insulin (FINS), liver coefficient, alanine aminotransferase (ALT), aspartate aminotransferase (AST), free fatty acids (FFA), serum adiponectin (ADP) were measured, and pathological changes in liver tissues of rats were observed.RESULTS Compared with normal control group, FBG, FINS, the liver coefficient, ALT, AST, FFA levels of rats in the model group were increased(P<0.05 or P<0.01); ADP content decreased (P<0.05). Compared with the model group, FBG, FINS, liver coefficient, ALT, AST, FFA levels of WERI high dose group rat were reduced (P<0.05 or P<0.01), ADP content was increased(P<0.05), the difference was statistically significant. The liver of the rosiglitazone group and WERI high, medium and low dose group were significantly improved.CONCLUSION WERI has a protective effect on the liver function of diabetic rats.