Hepatoprotective Effects of the Linderane on Liver Injury Model of Rats

OBJECTIVE To investigate the hepatoprotective effects of different doses of Linderane on liver injury using rat model. METHODS Sixty healthy male SD rats were randomly divided into 6 groups, which were control group, model group, linderane low-dose, medium-dose, high-dose group and positive control group. In addition to the control group, the other 5 groups were established liver injury model by carbon tetrachloride intraperitoneal injection. Each group was given either corresponding drug or the same volume of water during modeling. All the rats were killed after 6 weeks, and then the activity of ALT, AST, SOD, GSH-Px and the contents of MDA in serum were measured. The liver tissue sections were stained in order to observe their pathological changes. RESULTS Compared with the model group, linderane could decrease the activity of serum ALT and AST in model rats in a dose-dependent manner. The high-dose group could significantly increase the activity of serum SOD and GSH-Px, decrease serum MDA content, and significantly reduce the score of pathological changes of liver tissue in model rats. CONCLUSION The linderane could improve the antioxidant capacity against the liver injury induced by CCl₄ in rats.