Study on the Clinical Effects of Diabetic No. 1 Prescription of Traditional Chinese Medicine

OBJECTIVE To study the mechanism of diabetic No. 1 prescription of traditional Chinese medicine on inflammatory factors in initial treatment patients with type 2 diabetes mellitus. METHODS The 48 cases (2014-2015 years) of type 2 diabetes mellitus patients were randomly divided into the traditional Chinese medicine group and Western medicine group, 24 cases in each group. The western medicine group with Recombinant Human Insulin Lispro Injection (25R) combined with metformin treatment and Acarbose Tablet; the traditional Chinese medicine group was treated with the prescription of diabetes No. 1 Traditional Chinese medicine prescription. Recorded and compared before and after treatment in 2 groups of patients with body mass index (BMI), the changes of fasting blood glucose, interleukin 6, tumor necrosis factor alpha, interleukin 1 beta. RESULTS Compared with before treatment, the western medicine group and the traditional Chinese medicine group can effectively reduce the patient's fasting blood glucose(P<0.05) The Chinese medicine group could significantly reduce the expression of interleukin 6 and tumor necrosis factor alpha, interleukin 1 beta(P<0.05), but the western medicine group can not reduce the inflammatory factor;at the same time, there was no significant change in the BMI of the 2 groups(P>0.05). The incidence rate of adverse reaction of traditional Chinese medicine group was less than that of the control group(P<0.05). CONCLUSION Diabetes No.1 Prescription prescription can reduce blood sugar and inhibit inflammatory factors in patients with diabetes mellitus;at the same time, the incidence of adverse reactions such as hypoglycemia and gastrointestinal tract was relatively low, and the compliance was good. The prescription is suitable for diabetes mellitus induced by inflammatory factors, and its anti-inflammatory mechanism may be one of the mechanisms of the treatment of diabetes.