Study on the Compatibility of Cefpiramide Sodium and Metronidazole Injection

OBJECTIVE To investigate the compatibility of cefpiramide sodium for injection and metronidazole injection. METHODS The changes in pH value, appearance and insoluble particles were observed, and the relative contents of cefpiramide sodium and metronidazole were determined by HPLC in 8 h after mix at 5, 25, 35℃ under the condition of dark, indoor illumination and ultraviolet light. The limits of the related substances of cefpiramide sodium and metronidazole in the compatibility solution were investigated also. RESULTS In 4 h, cefpiramide sodium and metronidazole concentration didn't change significantly. The ultraviolet radiation had a certain effect on the stability of the mixture. CONCLUSION Cefpiramide sodium for injection can be combined with metronidazole injection in 4 h, but should avoid sunlight.