Antitumor Activity of Stearic Acid Grafted Chitosan Oligosaccharide Polymeric Micelles Loading Podophyllotoxin Against Human Glioma Cells

OBJECTIVE To investigate the effect of stearic acid grafted chitosan oligosaccharide polymeric micelles loading podophyllotoxin(CSO-SA/PPT) on the cell proliferation in human glioma cells. METHODS CSO-SA/PPT were prepared to investigate its physical and chemical properties. U87 cell proliferative activity was measured by tumor cell uptake assay and MTT assay. RESULTS The CSO-SA/PPT had greater inhibition on human glioma cells proliferation compared with free podophyllotoxin formulation. And in vitro drug uptake tests showed that CSO-SA/PPT presented more uptake characteristics than free podophyllotoxin. CONCLUSION CSO-SA/PPT plays an inhibitory role in the cell proliferation in human glioma cells.