| 引用本文: | 瞿建江,冯淑华,李可意.青蒿素脂质体的制备及质量评价[J].中国现代应用药学,2011,28(3):251-256. |
| QU Jianjiang,FENG Shuhua,LI Keyi.Preparation and Quality Evaluation of Artemisinin Liposomes[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(3):251-256. |
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| 摘要: |
| 目的 通过对青蒿素脂质体的处方和制备工艺研究，研制高包封率和稳定的脂质体。方法 采用乙醇注入法制备脂质体，以正交实验优化处方。测定了脂质体中药物的包封率；并初步考察了脂质体的稳定性。结果 优化处方与工艺所得脂质体形态均匀，包封率>85%，载药量达27.22%，粒径约为90 nm，Zeta电位约为-68.4 mV，具有良好的稳定性。结论 乙醇注入法制备脂质体工艺简便，包封率高，制备的脂质体稳定性好。 |
| 关键词: 青蒿素 脂质体 包封率 质量评价 |
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| Preparation and Quality Evaluation of Artemisinin Liposomes |
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QU Jianjiang1, FENG Shuhua2, LI Keyi2
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1.Medical College of Yangzhou University, Yangzhou 225001, China;2.Beijing Union University College of Biochemical Engineering, Beijing 100023, China
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| Abstract: |
| OBJECTIVE To get a stable artemisinin liposome with high trapping efficiency by selecting formulation and preparation of artemisinin liposome. METHODS The artemisinin liposomes were prepared by film-ultrasound method. The formulation was optimized by orthogonal design. The trapping efficiency and the stability were determined. RESULTS The trapping efficiency of the artemisinin liposome reached 85%, the drug amounted to 27.22%, the particle size of the liposome was 90 nm and the Zeta potential was -68.4 mV. The liposome had good stability. CONCLUSION The method can be used to prepare a stable artemisinin liposome with high trapping efficiency. |
| Key words: artemisinin liposomes trapping efficiency quality evaluation |
