| 引用本文: | 林小娟,黄小红,黄涓涓,蒋富强,张进华.利伐沙班药物利用评价标准的建立与应用[J].中国现代应用药学,2020,37(20):2543-2548. |
| LIN Xiaojuan,HUANG Xiaohong,HUANG Juanjuan,JIANG Fuqiang,ZHANG Jinhua.Establishment and Application of Drug Use Evaluation Standard of Rivaroxaban[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(20):2543-2548. |
|
| 摘要: |
| 目的 建立利伐沙班药物利用评价（drug use evaluation，DUE）标准，为临床合理应用利伐沙班提供参考。方法 以利伐沙班药品说明书为基础，参考相关指南和文献，并通过与临床专家讨论，从用药指征、用药过程和用药结果3个方面建立DUE标准。采用回顾性调查方法，对福建医科大学附属漳州市医院2018年1月—2019年6月使用利伐沙班的住院患者病历进行评价。结果 共纳入591份病历，用药合理率为60.41%，不合理用药情况主要为剂量偏小（27.75%）、超说明书用药（11.50%）和药物相互作用（9.64%）3方面。结论 建立的利伐沙班DUE标准有较强的科学性、实用性和可行性，在禁忌证、使用质子泵抑制剂预防利伐沙班相关胃黏膜损伤及超说明书用药的管理方面可进一步优化。 |
| 关键词: 利伐沙班 药物利用评价 标准 专家咨询法 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.20.020 |
| 分类号:R969.3 |
| 基金项目:福建省科技计划引导性项目（2018Y0037）；福建医科大学启航基金一般项目（2019QH1269） |
|
| Establishment and Application of Drug Use Evaluation Standard of Rivaroxaban |
|
LIN Xiaojuan1,2, HUANG Xiaohong1, HUANG Juanjuan1, JIANG Fuqiang1, ZHANG Jinhua2
|
|
1.Department of Pharmacy, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China;2.Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou 350001, China
|
| Abstract: |
| OBJECTIVE To establish the drug use evaluation(DUE) standard of rivaroxaban and provide a reference for the rationally clinical application of rivaroxaban. METHODS Based on the rivaroxaban drug label, related guidelines and literature, combined with clinical expert consultation results, DUE standard from three aspects(indications, medications and medication results) was established. A retrospective survey was conducted to evaluate the inpatients using rivaroxaban from January 2018 to June 2019 in Zhangzhou Affiliated Hospital of Fujian Medical University. RESULTS A total of 591 patients were included, with a medication reasonable rate of 60.41%. The irrational use of drugs was mainly in the low dose(27.75%), off-label medication(11.50%) and drug interactions(9.64%). CONCLUSION The rivaroxaban DUE standard established is scientific, practical and feasible. It can be further optimized in contraindications and use of proton pump inhibitors to prevent rivaroxaban-related gastric mucosal damage and the management of off-label medication. |
| Key words: rivaroxaban drug use evaluation standard expert consultation |
