| 引用本文: | 韦凌霞,丁茂鹏,王志旺,付晓艳,姚楠,庞亚蓉.cAMP/PKA/CREB信号通路调控组织器官细胞纤维化及中医药干预作用的研究进展[J].中国现代应用药学,2020,37(8):1019-1024. |
| WEI Lingxia,DING Maopeng,WANG Zhiwang,FU Xiaoyan,YAO Nan,PANG Yarong.Advances in Research on cAMP/PKA/CREB Signaling Pathway Regulating Tissue and Organ Cell Fibrosis and Intervention Effect of Traditional Chinese Medicine[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(8):1019-1024. |
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| 摘要: |
| 环磷酸腺苷（cAMP）通过活化cAMP依赖的蛋白激酶A（PKA），使cAMP反元件结合蛋白（CREB）磷酸化，从而调节基因转录，广泛参与神经系统的学习记忆过程，而近年来研究显示cAMP/PKA/CREB信号通路参与组织器官细胞的纤维化过程。机体损伤后在其组织器官细胞修复过程中，细胞外基质异常增生谓之纤维化，纤维化可使肝、肺、肾及心等脏器组织功能下降。中医药在治疗纤维化等慢性复杂疾病过程中有独特的优势，而调节cAMP/PKA/CREB信号通路是其防治组织器官细胞纤维化的机制之一。 |
| 关键词: cAMP/PKA/CREB信号通路 纤维化 中医药 研究进展 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.08.027 |
| 分类号:R285.5 |
| 基金项目:国家自然科学基金项目（81860787）；甘肃省高等学校科研基金项目（2015A-096） |
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| Advances in Research on cAMP/PKA/CREB Signaling Pathway Regulating Tissue and Organ Cell Fibrosis and Intervention Effect of Traditional Chinese Medicine |
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WEI Lingxia, DING Maopeng, WANG Zhiwang, FU Xiaoyan, YAO Nan, PANG Yarong
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School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China
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| Abstract: |
| Cyclic adenosine monophosphate(cAMP) phosphorylated cAMP counter-binding protein(CREB) by activating cAMP-dependent protein kinase A(PKA), thereby regulating gene transcription and is widely involved in the learning and memory processes of the nervous system. In recent years, studies have shown that the cAMP/PKA/CREB signaling pathway is involved in the fibrosis process of tissues and organs. During the repair process of tissue and organ cells after injury, the abnormal proliferation of extracellular matrix is fibrosis, and fibrosis can reduce the function of liver, lung, kidney and heart. Traditional Chinese medicine has unique advantages in the treatment of chronic and complex diseases such as fibrosis, and regulation of cAMP/PKA/CREB signaling pathway is one of the mechanisms for its prevention and treatment of tissue and organ cell fibrosis. |
| Key words: cAMP/PKA/CREB signaling pathway fibrosis traditional Chinese medicine research progress |
