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引用本文:贾路路,谭亲友.雷公藤红素抗肿瘤作用的研究进展[J].中国现代应用药学,2020,37(10):1260-1264.
JIA Lulu,TAN Qinyou.Progress in Anti-tumor Effect of Celastrol[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(10):1260-1264.
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雷公藤红素抗肿瘤作用的研究进展
贾路路, 谭亲友
桂林医学院, 广西 桂林 541001
摘要:
雷公藤红素为卫矛科植物雷公藤的主要活性成分之一,是一种醌甲基三萜类化合物,外观呈红色针状结晶体,具有多种生物学活性。2015年,雷公藤红素被发现具有显著减肥的作用,从而引起了大量学者的关注。近年来,越来越多的研究表明其在抗肿瘤方面具有较明显的药理活性,可通过多种信号通路抑制乳腺癌、前列腺癌、肺癌、结直肠癌、胃癌、肝癌等。本文就近年来雷公藤红素的抗肿瘤作用及其作用机制展开综述,旨在为雷公藤红素的深入研究提供新的思路。
关键词:  雷公藤红素  抗肿瘤  药理活性  研究进展
DOI:10.13748/j.cnki.issn1007-7693.2020.10.020
分类号:R284.1
基金项目:国家自然科学基金项目(81360665,81760747);广西自然科学基金项目(2015GXNSFAA139114,2013GXNSFBA019174);广西卫生厅中医药攻关课题(GZGG13-08)
Progress in Anti-tumor Effect of Celastrol
JIA Lulu, TAN Qinyou
Guilin Medical University, Guilin 541001, China
Abstract:
Celastrol is one of the main active ingredients of Tripterygium wilfordii. It is a quinone-methyl triterpene compound with red needle-like crystal appearance and has a lot of biological activities. In 2015, celastrol is found to have a super-slimming effect, which attract a lot of scholars' interest. In recent years, more and more studies have shown that it has obvious pharmacological activity in anti-tumor. It can inhibit breast cancer, prostate cancer, lung cancer, colorectal cancer, stomach cancer, liver cancer and the like through various signaling pathways. In this review, the anti-tumor effect of celastrol and its mechanism are described in order to provide new ideas for its further study.
Key words:  celastrol  anti-tumor  pharmacological activity  progress
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