| 引用本文: | 张晓芹,王娜妮,李亚平,陈礼平,贾敏,雷后兴,林娜.畲药白山毛桃根抗肿瘤作用及活性成分研究进展[J].中国现代应用药学,2019,36(22):2876-2879. |
| ZHANG Xaoqin,WANG Nani,LI Yaping,CHEN Liping,JIA Min,LEI Houxing,LIN Na.Research Progress of Anti-tumor Effects and Active Constituents of Actinidia Eriantha Benth. Root[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(22):2876-2879. |
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| 畲药白山毛桃根抗肿瘤作用及活性成分研究进展 |
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张晓芹1,2, 王娜妮2, 李亚平2, 陈礼平1, 贾敏3, 雷后兴1, 林娜1
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1.浙江省丽水市中医院, 浙江 丽水 323000;2.浙江省中医药研究院畲医药研究所, 杭州 310007;3.第二军医大学药学院, 上海 200433
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| 摘要: |
| 目的 综述畲药白山毛桃根抗肿瘤作用及活性成分研究进展，为白山毛桃根的临床应用和进一步开发提供参考依据。方法 检索1980—2018年以来国内外有关白山毛桃根的抗肿瘤作用及活性成分的研究论文，总结分析其抗肿瘤作用、抗肿瘤机制及活性成分。结果 白山毛桃根具有治疗胃癌、肝癌、黑色素瘤等多种抗肿瘤作用，其作用机制包括诱导细胞凋亡和坏死、免疫调节、阻滞细胞周期等，其抗肿瘤活性成分主要为乌苏酸类化合物。结论 白山毛桃根具有良好的抗肿瘤作用，临床应用价值较高，尚需加强其循证医学数据、抗肿瘤活性成分和质量标准的深入研究。 |
| 关键词: 白山毛桃根 抗肿瘤 作用机制 活性成分 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.22.027 |
| 分类号:R285.5 |
| 基金项目:浙江省中医药（中西医结合）重点学科建设项目（2017-XK-A50）；浙江省基础公益研究计划项目（LGF19H280002）；丽水市科技创新团队项目（2018cxtd06） |
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| Research Progress of Anti-tumor Effects and Active Constituents of Actinidia Eriantha Benth. Root |
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ZHANG Xaoqin1,2, WANG Nani2, LI Yaping2, CHEN Liping1, JIA Min3, LEI Houxing1, LIN Na1
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1.Lishui Hospital of Traditional Chinese Medicine, Lishui 323000, China;2.Institute of She Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, China;3.School of Pharmacy, The Second Military Medicinal Universiy, Shanghai 200433, China
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| Abstract: |
| OBJECTIVE To review the research progress of anti-tumor effects and active constituents of Actinidia eriantha Benth., in order to provide reference for the clinical application and further development of Actinidia eriantha Benth. root. METHODS The researches on anti-tumor and active constituents of Actinidia eriantha Benth. root from 1980 to 2018 were searched. The anti-tumor effect, mechanism and anti-tumor active ingredients were summarized and analyzed. RESULTS Actinidia eriantha Benth. root had various anti-tumor effects such as gastric cancer, liver cancer, nasopharyngeal carcinoma and cervical cancer. Its anti-tumor mechanism included regulating the expression of apoptosis-related genes, regulating immune regulation, arresting cell cycle and inhibiting proliferation and inducting apoptosis and necrosis, etc. Its anti-tumor active components were mainly triterpenoids. CONCLUSION Actinidia erantha Benth. root has good anti-tumor effect and high clinical value. It is necessary to strengthen its evidence-based medical data and in-depth study of anti-tumor active ingredients. |
| Key words: Actinidia eriantha Benth.root anti-tumor mechanism of action active ingredient |
