| 引用本文: | 郭俊林,邵青,吴琳琳,瞿海斌,杜新刚,龚行楚.山萸肉配方颗粒的制备工艺研究[J].中国现代应用药学,2019,36(22):2800-2804. |
| GUO Junlin,SHAO Qing,WU Linlin,QU Haibin,DU Xingang,GONG Xingchu.Production Process Optimization of Fructus Corni Formula Granules[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(22):2800-2804. |
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| 山萸肉配方颗粒的制备工艺研究 |
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郭俊林1,2, 邵青3, 吴琳琳3, 瞿海斌3, 杜新刚4, 龚行楚1,2,3
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1.江西中医药大学现代中药制剂教育部重点实验室, 南昌 330004;2.天津中医药大学研究生院, 天津 300193;3.浙江大学药学院药物信息学研究所, 杭州 310058;4.九洲方圆制药有限公司, 安徽 亳州 236800
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| 摘要: |
| 目的 优化山萸肉配方颗粒的提取、浓缩、干燥、制粒等制备工艺。方法 通过正交试验设计优化山萸肉提取工艺，利用单因素试验优化山萸肉的浓缩、干燥和制粒工艺。结果 山萸肉配方颗粒制备时提取工艺参数建议为加水量8.0 mL·g-1，浸泡30 min，提取2次，每次30 min；干燥工艺采用喷雾干燥，加饮片质量0.29倍的麦芽糊精，进风温度180℃，出风温度85℃，浓缩液密度为1.03 g·mL-1；制粒工艺采用干法制粒，辊轮速度10.0 r·min-1，辊轮压力为9.2 MPa。结论 优化所得提取、浓缩、干燥、制粒等工艺参数，可为山萸肉配方颗粒的生产提供参考。 |
| 关键词: 山茱萸 配方颗粒 制备工艺 提取 干燥 制粒 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.22.010 |
| 分类号:R283.6 |
| 基金项目:江西中医药大学现代中药制剂教育部重点实验室开放基金；天津市科技计划项目（15PTCYSY00030） |
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| Production Process Optimization of Fructus Corni Formula Granules |
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GUO Junlin1,2, SHAO Qing3, WU Linlin3, QU Haibin3, DU Xingang4, GONG Xingchu1,2,3
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1.Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;2.Tianjin University of Traditional Chinese Medicine, Graduate College, Tianjin 300193, China;3.Pharmaceutical Informatics Institute, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China;4.Jiuzhou Fangyuan Pharmaceutical Co., Ltd., Bozhou 236800, China
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| Abstract: |
| OBJECTIVE Process optimization of extraction, concentration, drying, and granulation of Fructus Corni formula granules. METHODS The extraction process of Fructus Corni was optimized by orthogonal design, and the processes of concentration, drying and granulation were optimized by a single-factor experiment method. RESULTS The optimized extraction process parameters were as follows:water of 8.0 mL·g-1, soaking for 30 min, extract twice, and 30 min of extraction time. Spray drying was recommended with inlet air temperature of 180℃, outlet air temperature of 85℃, and concentrate density of 1.03 g·mL-1. Dry granulation was favored with roller speed of 10.0 r·min-1 and roller pressure of 9.2 MPa. CONCLUSION The optimization results of extraction, concentration, drying, and granulation processes can help to implement the industrial production of Fructus Corni formula granules. |
| Key words: Fructus Corni formula granules preparation process extraction drying granulation |
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