坤泰胶囊联合克龄蒙治疗卵巢早衰疗效的荟萃分析

沈秋娴; 张璐璐; 林小杨; 梁元君; 刘冠彤; 卢如玲<sup>*</sup>

引用本文:	沈秋娴,张璐璐,林小杨,梁元君,刘冠彤,卢如玲.坤泰胶囊联合克龄蒙治疗卵巢早衰疗效的荟萃分析[J].中国现代应用药学,2020,37(1):78-84.
	SHEN Qiuxian,ZHANG Lulu,LIN Xiaoyang,LIANG Yuanjun,LIU Guantong,LU Ruling.Meta-analysis of the Efficacy of Kuntai Capsule Combined with Climen in the Treatment of Premature Ovarian Failure[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(1):78-84.

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坤泰胶囊联合克龄蒙治疗卵巢早衰疗效的荟萃分析
沈秋娴¹, 张璐璐¹, 林小杨¹, 梁元君¹, 刘冠彤¹, 卢如玲²
1.广州中医药大学, 广州 510405;2.广州中医药大学第一附属医院三妇科, 广州 510405

摘要:

目的系统评价坤泰胶囊联合克龄蒙治疗卵巢早衰的临床疗效，以期为临床提供循证参考。方法计算机搜索PubMed、Embase、Cochrane library、CNKI、VIP、万方数据库，收集关于坤泰胶囊联合克龄蒙治疗卵巢早衰的随机对照试验（randomized controlled trials，RCTs），2名研究者独立严格进行纳入研究的质量评价和资料提取，采用RevMan 5.2软件进行meta分析。结果最终纳入14个RCTs，共1 380例患者。Meta分析结果显示，与对照组比较，坤泰胶囊联合克龄蒙组总有效率[OR=3.76，95% CI=（2.49，5.70），P<0.000 01]、缓解临床症状（Kupperman评分）[MD=-3.95，95% CI=（-4.88，-3.03），P<0.000 01]、降低血中FSH水平[MD=-8.25，95% CI=（-10.70，-5.79），P<0.000 01]、提高血中E₂水平[MD=14.62，95% CI=（12.05，17.19），P<0.000 01]均存在明显优势，差异均有统计学意义；而在降低血中LH水平、降低不良反应发生率方面，则差异无统计学意义。结论坤泰胶囊联合克龄蒙治疗卵巢早衰具有一定疗效，但现有研究质量偏低，且数量偏少，需要更多高质量、多中心的随机双盲临床试验的进一步验证。

关键词: 坤泰胶囊克龄蒙卵巢早衰荟萃分析

DOI：10.13748/j.cnki.issn1007-7693.2020.01.015

分类号:R969.4

基金项目:张玉珍全国名老中医药专家传承工作室专项基金

Meta-analysis of the Efficacy of Kuntai Capsule Combined with Climen in the Treatment of Premature Ovarian Failure

SHEN Qiuxian¹, ZHANG Lulu¹, LIN Xiaoyang¹, LIANG Yuanjun¹, LIU Guantong¹, LU Ruling²

1.Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China;2.Women and Children Center the Third Department of Gynecology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China

Abstract:

OBJECTIVE To provide evidence for clinic by systematic evaluating the efficacy of Kuntai Capsule combined with Climen in the treatment of premature ovarian failure. METHODS The PubMed, Embase, Cochrane library, CNKI, VIP and WanFang databases were searched for randomized controlled trials(RCTs) of Kuntai Capsule combined with Climen in the treatment of premature ovarian failure. Two researchers independently and strictly conducted the quality evaluation and data extraction of the included studies, and meta analysis was conducted with RevMan 5.2 software. RESULTS A total of 14 RCTs were included, involved 1 380 patients. The results of meta-analysis showed that the total efficiency[OR=3.76, 95% CI=(2.49, 5.70), P<0.000 01], the score of Kupperman[MD=-3.95, 95% CI=(-4.88, -3.03), P<0.000 01], decreasing the serum levels of FSH[MD=-8.25, 95% CI=(-10.70, -5.79, P<0.000 01)] and increasing the serum levels of E₂[MD=14.62, 95% CI=(12.05, 17.19), P<0.000 01] in test group were better than control group, with statistical significance. But There was no statistical significance neither in decreasing the serum levels of LH nor reducing the incidence of adverse reactions between Kuntai Capsule combined with Climen group and control group. CONCLUSION Kuntai Capsule combined with Climen have potential advantages in the treatment of premature ovarian failure. However, the quality of existing research is low and the number is too small, which required more high-quality, multi-center randomized double-blind clinical trials for further validation.

Key words: Kuntai Capsule Climen premature ovarian failure meta-analysis