| 引用本文: | 冉姗,孙方方,宋燕,汪小莉,洪燕,韩燕全.基于代谢组学的哮喘三大物质代谢研究进展[J].中国现代应用药学,2019,36(20):2612-2617. |
| RAN Shan,SUN Fangfang,SONG Yan,WANG Xiaoli,HONG Yan,HAN Yanquan.Research Progress of Three Major Substances Metabolism of Asthma Based on Metabolomics[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(20):2612-2617. |
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| 基于代谢组学的哮喘三大物质代谢研究进展 |
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冉姗1,2, 孙方方1,2, 宋燕1,2, 汪小莉1, 洪燕2, 韩燕全1
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1.安徽中医药大学第一附属医院, 国家中医药管理局中药制剂三级实验室, 合肥 230031;2.安徽中医药大学, 合肥 230031
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| 摘要: |
| 哮喘是一种复杂的疾病，使用代谢组学技术分析哮喘具有独特的优势。为了更好地提高对哮喘病理生理学的理解及临床诊断，本文查阅近5年与哮喘相关的代谢组学文献，并在此基础上归纳总结出了在哮喘发生发展过程中体内三大物质代谢及代谢产物的变化规律，以期为哮喘的代谢组学研究及临床诊断、治疗提供一定的参考。 |
| 关键词: 哮喘 代谢组学 三大物质代谢 代谢产物 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.20.026 |
| 分类号:R285.5 |
| 基金项目:安徽省自然科学基金项目（1708085MH196） |
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| Research Progress of Three Major Substances Metabolism of Asthma Based on Metabolomics |
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RAN Shan1,2, SUN Fangfang1,2, SONG Yan1,2, WANG Xiaoli1, HONG Yan2, HAN Yanquan1
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1.The First Affiliated Hospital of Anhui University of Chinese Medicine, Grade 3 Laboratory of TCM Preparation, National Administration of Traditional Chinese Medicine, Hefei 230031, China;2.Anhui University of Chinese Medicine, Hefei 230031, China
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| Abstract: |
| It has unique advantages to use metabolomics in analyzing asthma, which is a complex disease. In order to improve the understanding of the pathophysiology of asthma and clinical diagnosis, therefore, this paper refer to nearly five years of metabonomics literature associated with asthma. Based on the literatures, this paper summarizes three major substances metabolism and metabolite about asthma, in order to provide a reference for the metabolomics research and clinical diagnosis, therapy of asthma. |
| Key words: asthma metabolomics three major substances metabolism metabolic biomarkers |
