| 引用本文: | 张彦焘,沈旭,郑运亮.丹参酮ⅡA对酸浆苦素D在大鼠体内药动学特性的影响[J].中国现代应用药学,2019,36(20):2518-2521. |
| ZHANG Yantao,SHEN Xu,ZHENG Yunliang.Effect of TanshinoneⅡA on Pharmacokinetic Characteristics of Physalin D in Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(20):2518-2521. |
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| 摘要: |
| 目的 研究丹参酮ⅡA对酸浆苦素D在大鼠体内药动学特性的影响。方法 12只SD大鼠随机分为对照组和丹参酮ⅡA组，分别灌胃生理盐水与丹参酮ⅡA，丹参酮ⅡA（50 mg·kg-1，每天1次）连续给药3 d后，酸浆苦素D灌胃给药后按时间点连续采样，采用HPLC-MS/MS测定酸浆苦素D在大鼠血浆中的含量，采用WinNolin 6.3软件计算主要药动学参数，2组间药动学参数采用SPSS 11.0统计软件对药动学参数进行t检验。结果 对照组和丹参酮ⅡA组酸浆苦素D的药动学参数间差异存在显著性差异（P<0.05），连续给药丹参酮ⅡA 3 d后给酸浆苦素D，酸浆苦素D的AUC0-24 h及Cmax均有显著提高。结论 丹参酮ⅡA能够显著影响酸浆苦素D在大鼠体内药动学过程。 |
| 关键词: 丹参酮ⅡA 酸浆苦素D 药动学 羧酸酯酶 相互作用 液质联用 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.20.005 |
| 分类号:R969.1 |
| 基金项目:浙江省自然科学基金项目（LY19H280011） |
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| Effect of TanshinoneⅡA on Pharmacokinetic Characteristics of Physalin D in Rats |
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ZHANG Yantao1, SHEN Xu2, ZHENG Yunliang2
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1.Guangzhou Health Science College, Guangzhou 510450, China;2.First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
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| Abstract: |
| OBJECTIVE To study the effect of carboxylesterase inhibitor(tanshinoneⅡA) on pharmacokinetic characteristics physalin D in rats. METHODS Twelve SD rats were randomly divided into the control group and tanshinone Ⅱ A group, which was administrated respectively with normal saline and tanshinone ⅡA. After pretreated with tanshinoneⅡA (50 mg·kg-1, qd) for 3 d, physalin D was given to the rats by intragastric administration. The plasma concentrations of physalin D were determined by HPLC-MS/MS. The main pharmacokinetic parameters were calculated by WinNonlin 6.3 software, pharmacokinetic parameters between two groups were then compared with t test by SPSS 11.0 software. RESULTS There had significant differences between the two groups in the main pharmacokinetic parameters of physalin D(P<0.05). AUC0-24 h and Cmax of oxymatrine D were significantly increased after continuous administration of tanshinone ⅡA for 3 d. CONCLUSION Ginsenone ⅡA can significantly influence the pharmacokinetic process of physalin D in rats. |
| Key words: tanshinone ⅡA physalin D pharmacokinetic carboxylesterase interaction LC-MS/MS |
