| 引用本文: | 王琳琳,朱涛,葛鹏玲.长链非编码RNA相关中药作用机制研究进展[J].中国现代应用药学,2019,36(15):1976-1979. |
| WANG Linlin,ZHU Tao,GE Pengling.Research Progress of Long Noncoding RNAs Related Mechanisms of Chinese Materia Medica[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(15):1976-1979. |
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| 摘要: |
| 中药是我国医药文化的瑰宝，有数千年的应用历史。然而，中药的作用机制尚未完全阐明，这在一定程度上限制了其临床应用。非编码RNA （nocoding RNA，ncRNA）是一类不能编码蛋白的转录体。几类ncRNA已被证实对疾病的发生和发展具有重要的调控作用，包括微小RNA、长链非编码RNA和环状RNA等。近年来，长链非编码RNA相关中药作用机制已成为研究热点。本文综述该领域研究进展，以期为中医药研究提供新思路。 |
| 关键词: 中药 长链非编码RNA 有效成分 微小RNA 环状RNA |
| DOI：10.13748/j.cnki.issn1007-7693.2019.15.025 |
| 分类号:R285.5 |
| 基金项目:“重大新药创制”国家科技重大专项（2012ZX09103201-018）；国家自然科学基金项目（81273650）；黑龙江省自然科学基金项目（LC2011C03）；黑龙江中医药大学“优秀创新人才支持计划”（2012RCD19）；黑龙江省博士后科研启动基金项目（LBH－Q15136）；哈尔滨市科技创新人才研究专项资金项目（2016RAXXJ100） |
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| Research Progress of Long Noncoding RNAs Related Mechanisms of Chinese Materia Medica |
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WANG Linlin, ZHU Tao, GE Pengling
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Heilongjiang University of Chinese Medicine, Harbin 150040, China
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| Abstract: |
| Chinese materia medica is the treasure of traditional Chinese medicine, which has been used for thousands of years. However, the mechanisms of Chinese materia medica have not been fully clarified, which limited its clinical application. Noncoding RNAs(ncRNAs) are non-protein coding transcripts. Several kinds of ncRNAs have proved to be important regulatory transcripts in the generation and progression of diseases, including microRNA, long noncoding RNA(lncRNA) and circular RNA, etc. The lncRNAs related mechanisms of Chinese materia medica has becoming a research hotspot in recent years. This paper reviewed the research progress on this research field and wish to provide new ideas for the study of traditional Chinese medicine. |
| Key words: Chinese materia medica long noncoding RNA active ingredients microRNA circular RNA |
