| 引用本文: | 柳兰,李雅,易丽娟,邹苏兰,彭仕杰.基于多指标综合评分法优选理气活血方挥发油提取包合工艺[J].中国现代应用药学,2019,36(11):1358-1362. |
| LIU Lan,LI Ya,YI Lijuan,ZOU Sulan,PENG Shijie.Optimization Extraction and Inclusion Process of Liqi Huoxue Recipe Volatile Oil Based on Multiple Index Comprehensive Evaluation Method[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(11):1358-1362. |
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| 摘要: |
| 目的 研究b-环糊精包合理气活血方混合挥发油的最佳工艺。方法 采用饱和水溶液法和研磨法对混合挥发油进行包合，通过正交试验设计对包合工艺条件进行优选，通过熵权法确定各指标的权重系数，采用薄层色谱法、红外光谱法对包合物进行验证。结果 最佳包合方法是饱和水溶液法，挥发油和b-环糊精的比例为1：10，转速为50 r·min-1，温度为40℃。结论 优选的包合工艺操作简便、工艺稳定、挥发油包合率和包合物得率高。 |
| 关键词: 挥发油 β-环糊精包合 正交试验 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.11.009 |
| 分类号:R943 |
| 基金项目:湖南省大学生研究性学习和创新性实验计划项目；湖南中医药大学一流学科建设项目（4901-0200002006） |
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| Optimization Extraction and Inclusion Process of Liqi Huoxue Recipe Volatile Oil Based on Multiple Index Comprehensive Evaluation Method |
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LIU Lan, LI Ya, YI Lijuan, ZOU Sulan, PENG Shijie
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Key Subjects of Pharmacy in Hunan University of Chinese Medicine, Changsha 410208, China
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| Abstract: |
| OBJECTIVE To optimize the the preparation process of the mixed volatile oil of Liqi Huoxue Recipe wrapped with b-cyclodextrin. METHODS Saturated aqueous solution method and grinding method were used to encapsulate the mixed volatile oil. The optimum encapsulation method was selected. The encapsulation conditions were optimized by orthogonal design. The weight coefficients of each index were determined by entropy weight method. Inclusion complexes were verified by TLC and IR. RESULTS The best inclusion method was saturated aqueous solution method. The ratio of volatile oil to b-cyclodextrin was 1:10, the rotational speed was 50 r·min-1, and the temperature was 40℃. CONCLUSION The optimized inclusion process is simple, stable and has high inclusion rate and high yield of volatile oil. |
| Key words: volatile oil β-cyclodextrin inclusion orthogonal test |
