芦荟胶外涂对大鼠背部创面愈合和疤痕形成的影响

袁慧杰; 廖紫琼; 欧阳道福; 李晓敏; 孙常磊; 陈明毅; 谢智勇; 赖志辉<sup>*</sup>

引用本文:	袁慧杰,廖紫琼,欧阳道福,李晓敏,孙常磊,陈明毅,谢智勇,赖志辉.芦荟胶外涂对大鼠背部创面愈合和疤痕形成的影响[J].中国现代应用药学,2018,35(1):53-56.
	YUAN Huijie,LIAO Ziqiong,OUYANG Daofu,LI Xiaomin,SUN Changlei,CHEN Mingyi,XIE Zhiyong,LAI Zhihui.Effect of Aloe Vera Gel on Wound Healing and Scar Formation in Back of Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(1):53-56.

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芦荟胶外涂对大鼠背部创面愈合和疤痕形成的影响
袁慧杰,廖紫琼,欧阳道福,李晓敏,孙常磊,陈明毅,谢智勇,赖志辉
1.中山大学生命科学学院, 广州 510275;2.中山大学药学院(深圳), 广东深圳 518000;3.完美(中国)有限公司, 广东中山 528400;4.中山大学测试中心, 广州 510275

摘要:

目的研究芦荟胶外涂对大鼠背部创面愈合及疤痕形成的影响。方法 36只健康♂大鼠随机分为空白组、实验组和对照组，建立大鼠背部切创伤模型，外涂创面给药后，以创伤面积愈合率和皮肤组织中毛囊、皮脂腺、胶原纤维等的生成情况来评价愈合效果。结果与空白组相比，实验组上皮出现时间早，创面愈合时间较短，伤口愈合率明显提高（P>0.05），皮肤组织中毛囊、皮脂腺等附属器官及Ⅲ型胶原纤维的生成较多，胶原蛋白束排列较为有序；实验组各项指标与对照组接近。结论芦荟胶对于皮肤创伤有着较好的治疗效果，并且可以抑制疤痕的形成。

关键词: 芦荟胶创面愈合抑制疤痕

DOI：10.13748/j.cnki.issn1007-7693.2018.01.012

分类号:R285.5

基金项目:国家自然科学基金项目（81473540，81473319）；广东省科技计划项目（2014A020221027，2014A020209026，2015A030401031）；中山市科技计划项目（2016C1015）

Effect of Aloe Vera Gel on Wound Healing and Scar Formation in Back of Rats

YUAN Huijie¹, LIAO Ziqiong², OUYANG Daofu³, LI Xiaomin³, SUN Changlei³, CHEN Mingyi², XIE Zhiyong², LAI Zhihui^1,4,5

1.School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China;2.School of Pharmaceutical Sciences, Sun Yat-sen University, Shenzhen 518000, China;3.Perfect(China) Company Limited, Zhongshan 528400, China;4.Instrumental Analysis & amp;5.Research Center, Sun Yat-sen University, Guangzhou 510275, China

Abstract:

OBJECTIVE To explore the effect of aloe gel on wound healing and scar formation in back of rats. METHODS Thirty-six healthy and male rats were randomly divided into blank control group, experimental group and control group, the model of dorsal wound in rats was established, after applied topically administered, the wound healing rate and the formation of hair follicles, sebaceous glands and collagen fibers in the skin tissues were evaluated. RESULTS Compared with the blank group, the appearing time of epithelium in the aloe gel group was earlier, the healing time was shorter, and the healing ratio was obviously improved (P>0.05), the contents of hair follicles, sebaceous glands and other accessory organs and type Ⅲ collagen fibers were more abundant in the skin tissues, collagen bundles were arranged more orderly. The indexes of the experimental group were close to that of the control group. CONCLUSION Aloe gel has a better therapeutic effect for skin trauma, and can inhibit the formation of scar.

Key words: aloe vera gel wound healing scar suppression