| 引用本文: | 张婧婷,马明华,吴闽枫,汪晓河,李福伦,年华.生肌化瘀方95%乙醇提取物对糖尿病小鼠创面的治疗作用[J].中国现代应用药学,2017,34(10):1369-1372. |
| ZHANG Jingting,MA Minghua,WU Minfeng,WANG Xiaohe,LI Fulun,NIAN Hua.Therapeutic Effect of 95% Ethanol Extract of Shengji Huayu Formula on Diabetic Wound[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(10):1369-1372. |
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| 生肌化瘀方95%乙醇提取物对糖尿病小鼠创面的治疗作用 |
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张婧婷1, 马明华2, 吴闽枫3, 汪晓河1, 李福伦3, 年华1
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1.上海中医药大学附属岳阳中西医结合医院, 药剂科, 上海 200437;2.上海市同济大学附属杨浦医院药剂科, 上海 200090;3.上海中医药大学附属岳阳中西医结合医院, 皮肤科, 上海 200437
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| 摘要: |
| 目的 探讨生肌化瘀方95%乙醇提取物对糖尿病小鼠创面愈合的影响。方法 采用体内动物试验研究生肌化瘀方95%乙醇提取物（低、中、高浓度）促进糖尿病创面的作用；通过对糖尿病小鼠大体观察，对创面面积、愈合时间、HE染色（肉芽新生、胶原修复、表皮迁移）等数据综合分析了解创面愈合的情况。结果 治疗第11天时阳性药组、95%乙醇提取物低剂量组创面面积明显小于模型组（P<0.05）；95%乙醇提取部位低浓度创面愈合率高于中、高浓度（P<0.05）。结论 生肌化瘀方95%乙醇提取物有明显促进创面愈合的作用。 |
| 关键词: 生肌化瘀方 95%乙醇提取物 创面愈合 HE染色 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.10.002 |
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| 基金项目:国家自然基金（81373648，81673866）；上海市卫计委科研课题项目（201440386）；上海市科学技术委员会科研计划项目（16411955000）；上海市进一步加快中医药事业发展三年行动计划（ZY3-RCPY-3-1041）；2016年度上海中医药大学校级医院管理研究项目（2016YG15） |
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| Therapeutic Effect of 95% Ethanol Extract of Shengji Huayu Formula on Diabetic Wound |
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ZHANG Jingting1, MA Minghua2, WU Minfeng3, WANG Xiaohe1, LI Fulun3, NIAN Hua1
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1.Pharmaceutial Center, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;2.Department of Pharmacy, Shanghai Yangpu Hospital, Tongji University, Shanghai 200090, China;3.Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
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| Abstract: |
| OBJECTIVE To investigate the effect of 95% ethanol extract of Shengji Huayu formula on wound healing in diabetic mice. METHODS In vivo animal experiment was used to study the effect of Shengji Huayu formula 95% ethanol extract(low, medium and high concentration) to promote the therapeutic effect of diabetic wound; based on diabetic mice (db/db mice), gross observation of the wound area, wound healing time, HE staining (new collagen repair, granulation, epidermal migration) comprehensive analysis data to understand the situation of wound healing. RESULTS On the eleventh day of treatment, the wound area of positive drug group and 95% ethanol group was significantly smaller than the model group (P<0.05), the wound healing rate of 95% ethanol extracts of low concentration was significantly higher than that in the middle, high concentration (P<0.05). CONCLUSION The 95% ethanol extract of Shengji Huayu formula can obviously promote wound healing. |
| Key words: Shengji Huayu formula 95% ethanol extract wound healing HE staining |
