| 引用本文: | 马趣环,石晓峰,沈薇,范彬,刘东彦,王新娣.糙叶败酱乙酸乙酯部位的化学成分研究[J].中国现代应用药学,2017,34(1):53-56. |
| MA Quhuan,SHI Xiaofeng,SHEN Wei,FAN Bin,LIU Dongyan,WANG Xindi.Chemical Constituents of Ethyl Acetate Fraction From Patrinia Scabra[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(1):53-56. |
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| 糙叶败酱乙酸乙酯部位的化学成分研究 |
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马趣环1, 石晓峰1,2, 沈薇1, 范彬1, 刘东彦1, 王新娣1
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1.甘肃省医学科学研究院药物研究所, 兰州 730050;2.甘肃省中药药理与毒理学重点实验室, 甘肃中医药大学, 兰州 730030
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| 摘要: |
| 目的 研究糙叶败酱乙酸乙酯部位的化学成分。方法 利用硅胶及Sephadex LH-20凝胶柱色谱对其化学成分进行分离、纯化，根据理化性质及波谱数据进行结构鉴定。结果 从糙叶败酱水提取物的乙酸乙酯萃取部位分离得到11个化合物，分别为7α-甲氧基莫罗苷（1）、7β-甲氧基莫罗苷（2）、1-辛醇（3）、2，3-壬烯烃（4）、lariciresinol（5）、Jatamanin J（6）、落叶松脂醇-4-O-β-D-葡萄糖苷（7）、黄花败酱醇（8）、Jatamanin A（9）、Scabroside A（10）、十六烷酸-α-单甘油酯（11）。结论 化合物1~4为首次从该植物中分离得到，其中化合物3，4为首次从败酱科败酱属植物中分离得到。 |
| 关键词: 糙叶败酱 乙酸乙酯部位 化学成分 结构鉴定 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.01.013 |
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| 基金项目:甘肃省中药药理与毒理学重点实验室开放课题（ZDSYS-KJ-2013-001）；甘肃省医学科学研究院中青年科技人才创新工程项目（ykz-2013-3） |
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| Chemical Constituents of Ethyl Acetate Fraction From Patrinia Scabra |
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MA Quhuan1, SHI Xiaofeng1,2, SHEN Wei1, FAN Bin1, LIU Dongyan1, WANG Xindi1
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1.Institute of Materia Medica, Gansu Academy of Medical Science, Lanzhou 730050, China;2.Key Laboratory of TCM Pharmacology and Toxicology of Gansu Province, Gansu College of TCM, Lanzhou 730030, China
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| Abstract: |
| OBJECTIVE To study the chemical constituents of ethyl acetate fraction from Patrinia scabra Bunge. METHODS Chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. RESULTS Eleven compounds were isolated and purified. Their structures were identified as 7α-O-methylmorroniside(1), 7β-O-methylmorroniside(2), 1-octanol(3), 2,3-nonyl olefin(4), lariciresinol (5), Jatamanin J(6), lariciresinol-4-O-β-D-glucopyrano-side(7), patriscabrol(8) Jatamanin A(9), Scabroside A(10), daturic acid 2, 3-dihydroxyopropyl(11). CONCLUSION Compounds 1-4 are isolated from this plant for the first time, the compound 3 and 4 were isolated from Patrinia Juss. for the first time. |
| Key words: Patrinia scabra Bunge ethyl acetate fraction chemical constituents structure identification |
