| 引用本文: | 赵桂芝,浦锦宝,周洁,梁卫青,胡轶娟,张宏建,徐攀.白术醇提物的抗炎镇痛活性研究[J].中国现代应用药学,2016,33(12):1507-1512. |
| ZHAO Guizhi,PU Jinbao,ZHOU Jie,LIANG Weiqing,HU Yijuan,ZHANG Hongjian,XU Pan.Study on Anti-inflammatory and Analgesic Effect of Ethanol Extract of Atractylodes Macrocephala Koidz[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(12):1507-1512. |
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| 白术醇提物的抗炎镇痛活性研究 |
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赵桂芝1,2, 浦锦宝1,2, 周洁1,2, 梁卫青1,2, 胡轶娟1,2, 张宏建1,2, 徐攀1,2
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1.浙江省中医药研究院, 杭州 310007;2.浙江省中药新药研发重点实验室, 杭州 310007
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| 摘要: |
| 目的 探讨白术醇提物的抗炎镇痛活性。方法 采用热板法测定白术不同剂量组小鼠的痛阈值，腹腔注射0.6%醋酸刺激致痛模型（扭体法）观察白术3个不同剂量的镇痛作用；采用二甲苯致小鼠耳廓肿胀实验和角叉菜胶致大鼠足肿胀实验观察3个不同剂量白术的抗炎作用。结果 高、中剂量的白术醇提物可显著增加小鼠的热板痛阈值（P<0.01），减少腹腔注射醋酸引起的小鼠扭体反应次数（P<0.01），而白术低剂量组不能有效的提高小鼠的痛阈值和减少扭体反应次数。在抗炎试验中，高、中剂量的白术醇提物可显著抑制小鼠耳廓肿胀度（P<0.01），而低剂量组对小鼠耳廓肿胀抑制效果不明显；高剂量组在2 h后能显著抑制大鼠足跖肿胀，中剂量组（除6 h时间点）与白术醇提物低剂量组（除3 h时间点）在药后0.5~6 h之间与模型组比较均无显著性差异。结论 白术醇提物具有较好的抗炎、镇痛作用，并呈现一定的剂量依赖性。 |
| 关键词: 白术 醇提物 抗炎 镇痛 |
| DOI：10.13748/j.cnki.issn1007-7693.2016.12.004 |
| 分类号:R285.5 |
| 基金项目:浙江省科技计划项目（2008F3036）；浙江省中医药科技计划项目（2013ZA006） |
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| Study on Anti-inflammatory and Analgesic Effect of Ethanol Extract of Atractylodes Macrocephala Koidz |
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ZHAO Guizhi1,2, PU Jinbao1,2, ZHOU Jie1,2, LIANG Weiqing1,2, HU Yijuan1,2, ZHANG Hongjian1,2, XU Pan1,2
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1.Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, China;2.Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province, Hangzhou 310007, China
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| Abstract: |
| OBJECTIVE To investigate the analgesic and anti-inflammatory activities of the ethanol extract of Atractylodes macrocephala Koidz. (EAM). METHODS Analgesic activity of EAM was evaluated by hot-plate test and acetic acid-induced writhing test on ICR mice, while anti-inflammatory activity of EAM was assessed by xylene-induced ear edema on ICR mice and carrageenan-induced rat paw edema on SD rats. RESULTS High and medium doses of the EAM could prolong the threshold time of pain(P<0.01), reduce the writhing times induced by acetic acid(P<0.01), and inhibit the edema induced by xylene and canageenan(P<0.01), while low dose of the EAM showed no siginificance differences compared to the control group in all experiments. In carrageenan-induced paw edema model, high dose of EAM could inhibit the paw swelling significantly since 2 h of administration, and in the period of 0.5-6 h after drug administration, medium dose of EAM (with the exception of 6 h) and low dose of EAM (with the exception of 3 h) had no significant differences compared with model group. CONCLUSION The ethanol extract of EAM has analgesic and anti-inflammatory effects, and present the dose-response relationship. |
| Key words: Atractylodes macrocephala Koidz. ethanol extract anti-inflammatory analgesic |
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