| 引用本文: | 程江雪,肖诗鹰,刘铜华.有效专利中防治呼吸系统疾病的中药复方用药规律探索[J].中国现代应用药学,2015,32(9):1073-1078. |
| CHENG Jiangxue,XIAO Shiying,LIU Tonghua.Regularity of Drug Use of Patents in Force of Traditional Chinese Herbal Compounds in Preventing and Treating Respiratory Diseases[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(9):1073-1078. |
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| 摘要: |
| 目的 探索防治呼吸系统疾病的中药复方有效专利的用药规律，为新药研制提供参考，为其专利保护提供战略依据。方法 以维持时间为5年的防治呼吸系统疾病的中药复方专利为研究对象，通过频数分析法对其核心药物的组成、分类、功效、归经及药对配伍进行统计分析。结果 防治呼吸系统疾病的中药复方有效专利中高频中药包括金银花、甘草、黄芩等22味，按照功效分类多属于清热药、化痰止咳平喘药和补虚药等，主要归肺、心经，高频药对配伍多来自于古(经)方。结论 上述用药规律探索体现了防治呼吸系统疾病中药复方的组方特点，为新的中药复方研发及专利保护策略提供了新思路。 |
| 关键词: 有效专利 中药复方 呼吸系统 频数分析 用药规律 |
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| Regularity of Drug Use of Patents in Force of Traditional Chinese Herbal Compounds in Preventing and Treating Respiratory Diseases |
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CHENG Jiangxue1, XIAO Shiying1,2, LIU Tonghua1
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1.Beijing University of Chinese Medicine, Beijing 100102, China;2.China National Center for Biotechnology Development, Beijing 100036, China
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| Abstract: |
| OBJECTIVE To research the regularity of drug use of patents in force of traditional Chinese herbal compounds in preventing and treating respiratory diseases, and provide a reference for the new Chinese drug development and evidence for the patent protection. METHODS With patents in force for 5 years of traditional Chinese medicine compounds in preventing and treating respiratory diseases as the study object, the frequency analysis was made for studying their core drug use, efficacy, channel tropism and drug compatibility. RESULTS There were 22 kinds of herbs such as Lonicerae Japonicae Flos, Glycyrrhizae Radix et Rhizoma, Scutellariae Radix used frequently in patents in force of traditional Chinese medicine compounds in preventing and treating respiratory diseases. According to the classification of efficacy, most herbs belonged to heat-clearing drugs, antitussive and antiasthmatic drugs and restoring vital energy drugs, the mainly channel tropism were lung meridian and heart meridian. A majority of the high-frequency compatibility of herb-partners were originated from the ancient(classical) prescriptions. CONCLUSION The result embodys the formula composing trait of the traditional Chinese herbal compounds in preventing and treating respiratory diseases, and provide a new idea for the development of new Chinese drugs and patent protection. |
| Key words: patent in force traditional Chinese medicine compounds respiratory system frequency analysis regularity of drug |
