| 引用本文: | 楼炜,周洁,岳素荣,王晓红,李伟,沈腾,王建新.散结止痛凝胶膏对乳腺增生模型大鼠的影响[J].中国现代应用药学,2015,32(6):656-659. |
| LOU Wei,ZHOU Jie,YUE Surong,WANG Xiaohong,LI Wei,SHEN Teng,WANG Jianxin.Therapeutic Experiment of Sanjiezhitong Cataplasm on Hyperplasia of Mammary Glands in Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(6):656-659. |
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| 散结止痛凝胶膏对乳腺增生模型大鼠的影响 |
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楼炜1, 周洁2,3, 岳素荣2,3, 王晓红4, 李伟3, 沈腾2, 王建新2
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1.浙江中医药大学附属第三医院，杭州 310005;2.复旦大学药学院，上海 201203;3.山东中医药大学药学院，济南 250355;4.上海复旦复华药业有限公司，上海 201111
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| 摘要: |
| 目的 研究散结止痛凝胶膏对乳腺增生模型大鼠的治疗作用，并探讨其作用机制。方法 采用肌注苯甲酸雌二醇及黄体酮建立大鼠乳腺增生模型，造模成功后，给药30 d，观察大鼠乳头形态变化，用放射免疫法测定大鼠血清性激素水平，并取乳腺组织做病理切片，观察组织病理学改变。结果 散结止痛凝胶膏能明显减小乳腺增生模型大鼠乳头高度，显著降低血清雌二醇水平，升高孕酮水平。病理组织学检查结果提示凝胶膏可显著减少乳腺增生小叶和腺泡的数量，改善导管上皮增生程度，抑制腺腔和导管腔分泌现象。结论 散结止痛凝胶膏对大鼠乳腺增生病有良好的治疗作用，能够有效调整大鼠体内性激素水平。 |
| 关键词: 散结止痛凝胶膏 乳腺增生 雌二醇 孕酮 |
| DOI： |
| 分类号:R284.1；R917.101 |
| 基金项目:“重大新药创制”国家科技重大专项(2009ZX09310-006)；上海市科学技术委员会科研计划项目(07DZ19713) |
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| Therapeutic Experiment of Sanjiezhitong Cataplasm on Hyperplasia of Mammary Glands in Rats |
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LOU Wei1, ZHOU Jie2,3, YUE Surong2,3, WANG Xiaohong4, LI Wei3, SHEN Teng2, WANG Jianxin2
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1.The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, China;2.School of Pharmacy, Fudan University, Shanghai 201203, China;3.School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;4.Shanghai Fudan Forward Pharmaceutical Co., Ltd., Shanghai 201111, China
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| Abstract: |
| OBJECTIVE To observe the therapeutic effect of Sanjiezhitong cataplasm on hyperplasia of mammary glands in rats, and to explore its mechanism. METHODS The model of mammary hyperplasia was established with i.m. injection of estradiol benzoate and progesterone per day, and the administration time was 30 d. The morphologic changes of nipple were recorded, the levels of serum sex hormone were determined by radio immunoassay and the morphologic change ofpathological tissue of mammary gland were observed. RESULTS Sanjiezhitong cataplasm could remarkably reduce the nipple height and efficiently decrease the level of estradiol and increase the level of progesterone. Histopathology examination showed that Sanjiezhitong cataplasm could decrease the number of alveolus in lobules of mammary gland, improve the degree of vessel epithelial proliferation, inhibit the secretion of alveolus and lactiferous ducts. CONCLUSION Sanjiezhitong cataplasm have the good therapeutic effect on hyperplasia of mammary glands in rats and can improve the level of sex hormone efficiently. |
| Key words: Sanjiezhitong cataplasm hyperplasia of mammary glands estradiol progesterone |
